Moderate-intensity dynamic resistance training lowered mean arterial pressure (159±2.2 vs 177±3.4 mmHg) and resting heart rate (332±9.0 vs 356±5 bpm) in hypertensive ovariectomized rats.
Does resistance exercise training decrease sympathetic tone and blood pressure in hypertensive ovariectomized rats?
Moderate-intensity dynamic resistance training attenuates the additional arterial pressure increase caused by ovarian hormone deprivation in hypertensive rats, associated with reduced cardiac sympathetic tone.
Absolute Event Rate: 159% vs 177%
The aim of this study was to investigate the effects of resistance exercise training on hemodynamics and cardiac autonomic control in ovariectomized spontaneously hypertensive rats. Female rats were divided into 4 groups: sedentary control (SC), sedentary hypertensive (SH), sedentary hypertensive ovariectomized (SHO), and resistance-trained hypertensive ovariectomized (RTHO). Resistance exercise training was performed on a vertical ladder (5 days/week, 8 weeks) at 40-60% maximal load. Direct arterial pressure was recorded. Vagal and sympathetic tones were measured by heart rate (HR) responses to methylatropine (3 mg/kg, iv) and propranolol (4 mg/kg, iv). Ovariectomy resulted in additional increases in blood pressure in hypertensive rats and was associated with decreased vagal tone. Resistance exercise trained rats had lower mean arterial pressure than untrained rats (RTHO: 159±2.2 vs SHO: 177±3.4 mmHg), as well as resting bradycardia (RTHO: 332±9.0 vs SHO: 356±5 bpm). Sympathetic tone was also lower in the trained group. Moreover, sympathetic tone was positively correlated with resting HR (r=0.7, P<0.05). The additional arterial pressure increase in hypertensive rats caused by ovarian hormone deprivation was attenuated by moderate-intensity dynamic resistance training. This benefit may be associated with resting bradycardia and reduced cardiac sympathetic tone after training, which suggests potential benefits of resistance exercise for the management of hypertension after ovarian hormone deprivation.
Shimojo et al. (Thu,) conducted a other in Hypertension and ovarian hormone deprivation. Resistance exercise training vs. Sedentary hypertensive ovariectomized (SHO) was evaluated on Mean arterial pressure. Moderate-intensity dynamic resistance training lowered mean arterial pressure (159±2.2 vs 177±3.4 mmHg) and resting heart rate (332±9.0 vs 356±5 bpm) in hypertensive ovariectomized rats.