Primary aldosteronism was associated with significantly higher pulse wave velocity compared to essential hypertension and normotensive controls (9.8 vs 7.5 vs 5.9 m/sec; P<0.001).
Cross-Sectional (n=84)
Does primary aldosteronism increase arterial wall stiffness compared to essential hypertension and normotensive controls?
Primary aldosteronism is associated with independently increased arterial wall stiffness compared to essential hypertension, suggesting deleterious effects of aldosterone excess on vascular remodeling.
Absolute Event Rate: 9.8% vs 7.5%
p-value: p=<.001
BACKGROUND: Aldosterone has been shown to substantially contribute to the accumulation of collagen fibers and growth factors in the arterial wall, which can increase wall stiffness. This study aimed at comparing arterial stiffness between patients with primary aldosteronism (PA), essential hypertension (EH), and normotensive controls using carotid-femoral pulse wave velocity (PWV) and central augmentation index (AI). METHODS: Thirty-six patients with confirmed PA, 28 patients with EH, and 20 normotensive subjects were investigated by Sphygmocor applanation tonometer. RESULTS: The office blood pressure (BP) at the time of the measurement (PA 167+/-34/92+/-12 mm Hg; EH 166+/-19/91+/-10 mm Hg), age, body mass index (BMI), cholesterol, triglyceride, blood glucose levels were comparable between PA and EH groups. The patients with PA had significantly higher PWV than the EH patients and control subjects (9.8+/-2.6 m/sec v 7.5+/-1.0 m/sec v 5.9+/-0.7 m/sec, respectively; all mutual differences P<.001). The difference in PWV between PA and EH remained statistically significant also after the adjustment for all clinical variables including 24-h BP using multivariate analysis (P=.001). CONCLUSIONS: Arterial wall stiffness is independently increased in PA compared to EH. This could be caused by the deleterious effects of aldosterone excess (potentially modulated by hypernatremia) on the fibrosis and remodeling of the arterial wall.
Štrauch et al. (Wed,) conducted a cross-sectional in Primary aldosteronism and essential hypertension (n=84). Primary aldosteronism vs. Essential hypertension and normotensive controls was evaluated on Carotid-femoral pulse wave velocity (PWV) (p=<.001). Primary aldosteronism was associated with significantly higher pulse wave velocity compared to essential hypertension and normotensive controls (9.8 vs 7.5 vs 5.9 m/sec; P<0.001).