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The mechanism of biomaterial associated thrombosis has not been fully elucidated. It is believed that surface wettability of biomaterials is a key factor in influencing thrombogenicity. Parallel grating microstructure poly(dimethylsiloxane) (PDMS) surfaces were designed and fabricated using soft lithography. The surface morphology is observed using scanning electron microscopy. The average contact angles for water droplet on the flat PDMS surface and parallel grating surface were 114·7 and 161·8° respectively, and the sliding angles were ∼19 and <4° respectively. The blood platelet adhesion test was carried out to study the blood compatibility of the surface. The experimental result of blood platelet adhesion demonstrated that the amount of adsorbed blood platelet on the parallel grating microstructure surface was fewer, and no distortion and no activation were found, as compared with the smooth surface. It may be that the suitable wettability could be a reason for the observed variation in hemocompatibility between the textured surface and the smooth surface.
G. Li (Mon,) studied this question.
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