Salivary high-sensitivity cardiac troponin T levels were significantly higher in acute MI patients versus healthy controls and correlated significantly with serum levels (r=0.466, P<0.021).
Case-Control (n=60)
No
Does salivary hs-cTnT correlate with serum hs-cTnT and accurately identify patients with acute myocardial infarction?
Salivary hs-cTnT levels are significantly elevated in acute MI and correlate with serum levels, suggesting a potential non-invasive diagnostic tool.
Effect estimate: r = 0.466
p-value: p=<0.021
OBJECTIVE: Accurate and rapid diagnosis of acute myocardial infarction (MI) is of major medical and economic importance. The objective of this study was to identify whole saliva high-sensitivity cardiac troponin T (hs-cTnT) in patients with acute MI. SUBJECTS AND METHODS: A case-control study was carried out in 30 normal healthy individuals, and 30 patients with acute MI were hospitalized in CCU of Imam Hossein hospital, Tehran, Iran. The hs-cTnT levels were assayed in serum and whole saliva in the first and second morning following the MI by ELISA method. Statistical analysis of the Student's t-test and Pearson correlation coefficient was performed. RESULTS: The mean stimulated and unstimulated saliva and serum levels of hs-cTnT at both the first and the second morning following the acute MI were significantly higher in patients with acute MI compared with healthy individuals. Furthermore, stimulated and unstimulated saliva hs-TnT levels correlated significantly with serum hs-TnT level (r = 0.415, P < 0.023; r = 0.466, P < 0.021, respectively). CONCLUSION: Results suggest that salivary hs-cTnT can be used as an alternative to serum hs-cTnT for diagnosis and monitoring of myocardial infarction.
Mirzaii‐Dizgah et al. (Sun,) conducted a case-control in Acute myocardial infarction (n=60). Salivary high-sensitivity cardiac troponin T (hs-cTnT) measurement vs. Healthy individuals and serum hs-cTnT was evaluated on Saliva and serum levels of hs-cTnT and their correlation (r = 0.466, p=<0.021). Salivary high-sensitivity cardiac troponin T levels were significantly higher in acute MI patients versus healthy controls and correlated significantly with serum levels (r=0.466, P<0.021).
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