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During the past 5½ years 152 patients have undergone multiple valve replacement in this clinic. The operative mortality is 12% and the late mortality 14%. The late complications and functional results of the 112 survivors are reviewed and discussed. Neither severe cardiovascular symptoms nor unfavorable hemodynamic findings are specific contraindications to an operation; however, irreversible disease coexisting in other organ systems is a possible contraindication. A decrease in recent operative mortality and fewer significant complications suggest that this experience should be extended.
Bigelow et al. (1968) studied this question.