Computational simulation of blood flow in a permeable T-junction showed higher LDL concentration at the luminal surface, reducing to 40% at 1 mm depth and 20% at 2 mm depth.
Computational fluid dynamics modeling demonstrates that LDL concentration is highest at the luminal surface of a T-junction and decreases progressively with depth into the arterial wall.
Previous studies indicate that blood flow and transport of macromolecules in the cardiovascular system and tissues are essential to understand the genesis and progression of arterial diseases and for the effective implementation of arterial grafts, as well as to devise efficient drug delivery mechanisms. In the present study, we use computational fluid dynamics to simulate the blood flow and transport of low-density lipoproteins (LDL) in a three-dimensional and permeable T junction. The Navier-Stokes equation, Darcy's Law, and the advective diffusion equations are the mathematical models used to simulate the flow and transport phenomena of the system. In the numeric model to implement the finite volume method, we used the computational fluid dynamics software Fluent 6.1. The simulation shows higher LDL concentration in the luminal surface at the junction under physiologic flow conditions. At 1 mm depth into the artery from the luminal surface, the LDL concentration is approximately 40% of the lumenal concentration, and at 2 mm depth, it reduces to 20%. Ultimately, the concentration drops further and reaches zero at the outer wall boundary.
Shibeshi et al. (Sun,) conducted a other in Arterial diseases. Computational fluid dynamics simulation was evaluated on LDL concentration. Computational simulation of blood flow in a permeable T-junction showed higher LDL concentration at the luminal surface, reducing to 40% at 1 mm depth and 20% at 2 mm depth.
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