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Synthesis of commercially available benzimidazole involves condensation of o-phenylenediamine with formic acid. The most prominent benzimidazole compound in nature is N-riosyldimethylbenzimidazole, which serves as a axial ligand for cobalt in vitamin B12. The benzimidazole and its derivatives play a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. Apart from this the benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, etc. The substituted benzimidazoles are summarized in this review to know about the chemistry as well as pharmacological activities.
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Salahuddin Salahuddin
Mohammad Shahar Yar
Avijit Mazumder
Arabian Journal of Chemistry
Jamia Hamdard
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Salahuddin et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69fef0e5413f0c047f2d59a3 — DOI: https://doi.org/10.1016/j.arabjc.2012.07.017