July 1, 2009

Why Does the Randomized Clinical Trial Methodology So Often Mislead Clinical Decision Making?: Focus on Moderators and Mediators of Treatment

HKHelena C. KraemerWesleyan University RGRobert D. GibbonsChicago Department of Public Health

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Abstract

CME Educational Objectives 1. Review moderators and mediators of treatment efficacy and effectiveness. 2. Identify limitations of randomized clinical trials for generalizing to the population. 3. Identify moderators and mediators for treatment-related effects.

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Kraemer et al. (Wed,) studied this question.

synapsesocial.com/papers/6a1d439f1e7099f691052805 https://doi.org/https://doi.org/10.3928/00485713-20090625-06