Potassium channel modulators possess certain natural-product scaffolds and pharmacokinetic properties that can be differentiated using in silico methods to facilitate translational research.
This review summarizes the structural features, regulation mechanisms, and modulators of potassium channels, providing insights for future translational research and drug targeting.
Potassium channels participate in many critical biological functions and play important roles in a variety of diseases. In recent years, many significant discoveries have been made which motivate us to review these achievements. The focus of our review is mainly on three aspects. Firstly, we try to summarize the latest developments in structure determinants and regulation mechanism of all types of potassium channels. Secondly, we review some diseases induced by or related to these channels. Thirdly, both qualitative and quantitative approaches are utilized to analyze structural features of modulators of potassium channels. Our analyses further prove that modulators possess some certain natural-product scaffolds. And pharmacokinetic parameters are important properties for organic molecules. Besides, with in silico methods, some features that can be used to differentiate modulators are derived. There is no doubt that all these studies on potassium channels as possible pharmaceutical targets will facilitate future translational research. All the strategies developed in this review could be extended to studies on other ion channels and proteins as well.
Tian et al. (Sat,) conducted a review in Potassium channel-related diseases. Potassium channel modulators was evaluated. Potassium channel modulators possess certain natural-product scaffolds and pharmacokinetic properties that can be differentiated using in silico methods to facilitate translational research.
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