Matrix metalloproteases play key roles in post-myocardial infarction cardiac remodeling and represent potential therapeutic targets requiring further pre-clinical and clinical investigation.
This review highlights the role of matrix metalloproteases in post-MI cardiac remodeling and their potential as therapeutic targets.
Myocardial infarction (MI) remains a major cause of morbidity and mortality worldwide. Rapid advances in the treatment of acute MI have significantly improved short-term outcomes in patients, due in large part to successes in preventing myocardial cell death and limiting infarct area during the time of ischemia and subsequent reperfusion. Matrix metalloproteases (MMPs) play key roles in post-MI cardiac remodeling and in the development of adverse outcomes. This review highlights the importance of MMPs in the injury and remodeling response of the left ventricle and also discusses their potential as therapeutic targets Additional pre-clinical and clinical research is needed to further investigate and understand the cardioprotective effects of MMPs inhibitors.
Yabluchanskiy et al. (Tue,) conducted a review in Myocardial infarction. Matrix metalloprotease (MMP) inhibitors was evaluated. Matrix metalloproteases play key roles in post-myocardial infarction cardiac remodeling and represent potential therapeutic targets requiring further pre-clinical and clinical investigation.