Chronic treatment with captopril (100 mg/kg daily) induced progressive reductions in blood pressure, resulting in normalization of pressure and cardiac hypertrophy after 6 months in hypertensive rats.
Does captopril reduce mean arterial blood pressure and cardiac hypertrophy in spontaneously hypertensive rats compared to hydralazine?
Chronic ACE inhibition with captopril normalizes blood pressure and reverses cardiac hypertrophy in a normal-renin model of hypertension.
The effects of hydralazine (3 mg/kg) and the angiotensin I-converting enzyme (ACE) inhibitor captopril (SQ 14,225) (100 mg/kg) on mean arterial blood pressure, plasma renin activity, urinary volume and urinary Na+,K+, and aldosterone concentrations were examined in spontaneously hypertensive rats of the Okamoto and Aoki strain (SHR) after oral daily dosing for 2 weeks, 3 or 6 months. Captopril caused progressive cumulative reductions in blood pressure resulting in normalization of pressure after 6 months of dosing. Hydralazine also significantly reduced blood pressure but not to the level of normotensive rats of the Wistar-Kyoto strain (WKY). Reductions in heart size paralleled the changes in blood pressure, normalization of cardiac hypertrophy occurring after captopril but not hydralazine. Plasma renin activity increased approximately 2-3 fold after hydralazine and 15-fold after captopril. Neither hydralazine nor captopril had any consistent effects on 24-hr urine volume, urinary Na+,K+ or aldosterone excretion. These results indicate that chronic inhibition of ACE with captopril induces normalization of blood pressure in SHR, a normal-renin model of hypertension.
Antonaccio et al. (Mon,) conducted a other in Hypertension. Captopril (SQ 14,225) vs. Hydralazine (3 mg/kg) and normotensive rats (WKY) was evaluated on Mean arterial blood pressure, plasma renin activity, urinary volume and urinary Na+,K+, and aldosterone concentrations. Chronic treatment with captopril (100 mg/kg daily) induced progressive reductions in blood pressure, resulting in normalization of pressure and cardiac hypertrophy after 6 months in hypertensive rats.