Quantitative Studies of Human Leukocytic and Febrile Response to Single and Repeated Doses of Purified Bacterial Endotoxin*

Bacterial endotoxins injected intravenously in small doses into animals and man produce, among other effects, a transient granulocytopenia fol- lowed by a marked granulocytosis (1-7). Sev- eral comprehensive reviews have recently ap- peared which deal with the wide spectrum of bio- logic effects of these substances, including their relationship to the pathogenesis of fever, the development of tolerance to repeated administration, and effects upon host resistance to bacterial in- fection (5, 8, 9).