Electroanatomic mapping during distal coronary sinus pacing demonstrated a single transseptal breakthrough near the CS ostium in all 16 patients, with a total septal activation time of 68 ± 16 ms.
Observational (n=16)
What are the electrophysiological properties of transseptal conduction during distal coronary sinus pacing in patients with paroxysmal atrial fibrillation?
In patients with paroxysmal AF, distal CS pacing reveals a preferential site of transseptal conduction near the CS ostium, providing important anatomical targets for catheter ablation.
OBJECTIVE: To delineate the electrophysiological properties of transseptal conduction from the left to the right atrium in patients with paroxysmal atrial fibrillation (AF). DESIGN AND RESULTS: Right atrial mapping using the electroanatomic mapping technique was performed at 111 +/- 16 sites in 16 patients with paroxysmal AF during pacing from distal coronary sinus (CS). A single transseptal breakthrough near the CS ostium was observed in all patients. The activation time from the pacing site to the earliest septal activation site was 47 +/- 13 ms. The total septal activation time (68 +/- 16 ms) was markedly longer but the total right atrial activation time (118 +/- 17 ms) was similar to that in patients without AF in a previous observation. CONCLUSION: During distal CS pacing, a preferential site of transseptal conduction near the CS ostium was demonstrated in patients with paroxysmal AF. This has clinical implications when surgical dissection or catheter ablation is considered to eliminate interatrial connection in patients with AF.
Hertervig et al. (2003) conducted an observational in Paroxysmal atrial fibrillation (n=16). Electroanatomic mapping during distal coronary sinus pacing vs. Historical control (patients without AF) was evaluated on Electrophysiological properties of transseptal conduction (activation times and breakthrough sites). Electroanatomic mapping during distal coronary sinus pacing demonstrated a single transseptal breakthrough near the CS ostium in all 16 patients, with a total septal activation time of 68 ± 16 ms.