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In addition to other alterations found in failing hearts, the diminished response to beta-receptor agonists appears to involve the combined effects of enhanced expression of beta ARK and reduced expression of beta 1-receptors.
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Martin Ungerer
Bioscience Research
Michael Böhm
Heart Failure & Transplant
John S. Elce
Queen's University
Circulation
Max Planck Institute of Biochemistry
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Ungerer et al. (Mon,) studied this question.
synapsesocial.com/papers/69eedef3a84321e0ae63c615 — DOI: https://doi.org/10.1161/01.cir.87.2.454