October 2, 1980
View Full PaperImproved Diastolic Function and Systolic Performance in Hypertrophic Cardiomyopathy after Nifedipine
Key Result
Treatment with nifedipine in a 54-year-old woman with severe non-obstructive hypertrophic cardiomyopathy improved diastolic compliance and systolic performance, and relieved dyspnea and chest pain.
Study Design
Type
Case Report (n=1)
Multicenter
No
Structured PICO
Does nifedipine improve diastolic function and symptoms in a patient with severe non-obstructive hypertrophic cardiomyopathy?
P
Population
54-year-old woman with severe hypertrophic cardiomyopathy without obstruction, presenting with progressive exertional dyspnea and chest pain (n=1)
I
Intervention
Nifedipine
O
Outcome
Diastolic compliance, systolic performance, and relief of symptoms (dyspnea and chest pain)surrogate
Nifedipine may improve diastolic compliance, systolic performance, and symptoms in patients with severe non-obstructive hypertrophic cardiomyopathy.
Abstract
WE report the case of a 54-year-old woman with severe hypertrophic cardiomyopathy without obstruction, in whom treatment with the calcium-channel blocking agent nifedipine improved both diastolic compliance and systolic performance, and relieved the symptoms of dyspnea and chest pain. These observations emphasize the importance of impaired diastolic function in hypertrophic cardiomyopathy and focus attention on the potential of a new class of agents in treatment of this disorder.Case HistoryA 54-year-old woman was admitted for evaluation of progressive, exertional dyspnea and chest pain. Cardiac catheterization, performed elsewhere when she was 36 and 46 years old, had revealed normal left . . .