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Three new neolignans, piperulins corrected A 1, B 2, and C 3, were isolated from Piper puberulum. Their structures and relative stereochemistries were determined from spectral data and the X-ray crystallographic analysis of 1. Compounds 1 and 3 inhibit specific platelet activating factor receptor binding with IC50 values of 7.3 and 5.7 microM, respectively.
Zhang et al. (Sat,) studied this question.