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Published data do not allow evaluation of whether antibacterials in temporary cement spacers provide additional benefits in the treatment of PJI, compared with systemic antibacterials, and are not sufficient to support recommendations on dosages. Complications of ACSs have not been consistently analyzed. Prospective randomized trials comparing spacers with and without antibacterials or spacers with different loads of antibacterials are needed to evaluate the safety and efficacy of ACSs.
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Dmitri Iarikov
Center for Drug Evaluation and Research
Hany W. Demian
Daniel B. Rubin
Harvard University
Clinical Infectious Diseases
Center for Drug Evaluation and Research
Center for Devices and Radiological Health
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Iarikov et al. (Thu,) studied this question.
synapsesocial.com/papers/69d7c4f261e2ce1627d17e20 — DOI: https://doi.org/10.1093/cid/cis735