Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia

Article1 February 1966Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute LeukemiaGERALD P. BODEY, M.D., MONICA BUCKLEY, B.A., Y. S. SATHE, PH.D., EMIL J FREIREICH, M.D.GERALD P. BODEY, M.D., MONICA BUCKLEY, B.A., Y. S. SATHE, PH.D., EMIL J FREIREICH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-328 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInfection is currently the major fatal complication of acute leukemia (1). Previous studies have indicated a relationship between leukopenia and the presence of infection in patients with acute leukemia (2-4) and various types of agranulocytosis (5-7). Chemotherapeutic agents with bone marrow toxicity are being used with increasing frequency in malignant and other chronic diseases. Also, a high incidence of infection has accompanied the use of these agents as immunosuppressive therapy in patients receiving organ transplantation (8). The present study examines the quantitative relationships between the presence of infection and the degree and duration of leukopenia in patients with acute leukemia....References1. HERSHBODEYNIESFREIREICH EMGPBAEJ: The causes of death in acute leukemia. A study of 414 patients from 1954-1963. JAMA 193: 105, 1965. CrossrefMedlineGoogle Scholar2. MILLERSHANBROM SPE: Infectious syndromes of leukemias and lymphomas. Amer. J. Med. Sci. 246: 420, 1963. CrossrefMedlineGoogle Scholar3. SILVERBEALSCHNEIDERMANMCCULLOUGH RTGAMANB: The role of the mature neutrophil in bacterial infections in acute leukemia. Blood 12: 814, 1957. CrossrefMedlineGoogle Scholar4. BAKER RD: Leukopenia and therapy in leukemia as factors predisposing to fatal mycoses. Mucormycosis, aspergillosis, and cryptococcosis. Amer. J. Clin. Path. 37: 358, 1962. 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HERSHCARBONEWONGFREIREICH EMPPVGEJ: Inhibition of the primary immune response in man by antimetabolites. Cancer Res. In press. Google Scholar18. JAFFE RH: Morphology of the inflammatory defense reactions in leukemia. Arch. Path. (Chicago) 14: 177, 1932. Google Scholar19. BRAUDEFELTESBROOKS AIJM: Differences between the activities of mature granulocytes in leukemic and normal blood. J. Clin. Invest. 33: 1036, 1954. CrossrefMedlineGoogle Scholar20. BOGGS DR: The cellular composition of inflammatory exudates in human leukemias. Blood 15: 466, 1960. CrossrefMedlineGoogle Scholar21. PERILLIEFINCH PEC: The local exudative cellular response in leukemia. J. Clin. Invest. 39: 1353, 1960. CrossrefMedlineGoogle Scholar22. PERILLIEFINCH PESC: Quantitative studies of the local exudative cellular reaction in acute leukemia. J. Clin. Invest. 43: 425, 1964. CrossrefMedlineGoogle Scholar23. PAGEGOOD ARRA: A clinical and experimental study of the function of neutrophils in the inflammatory response. Amer. J. Path. 34: 645, 1958. MedlineGoogle Scholar24. RAABHOEPRICHWINTROBECARTWRIGHT SOPDMMGE: The clinical significance of fever in acute leukemia. Blood 16: 1609, 1960. CrossrefMedlineGoogle Scholar25. MILLER CP: The effect of irradiation on natural resistance to infection. Ann. N. Y. Acad. Sci. 66: 280, 1956. CrossrefGoogle Scholar26. DERBYROGERS BMDE: Studies on bacteremia. V. The effect of simultaneous leukopenia and reticuloendothelial blockade on the early blood stream clearance of staphylococci and Escherichia coli. J. Exp. Med. 113: 1053, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Medicine Branch, Leukemia Service, and the Mathematical and Statistics and Applied Mathematical Section, National Cancer Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Gerald P. Bodey, M.D., Building 10, Room 2B45, National Institutes of Health, Bethesda, Md. 20014. 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