Key points are not available for this paper at this time.
The neuropathological hallmarks of Alzheimer disease (AD) include "positive" lesions such as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial responses, and "negative" lesions such as neuronal and synaptic loss. Despite their inherently cross-sectional nature, postmortem studies have enabled the staging of the progression of both amyloid and tangle pathologies, and, consequently, the development of diagnostic criteria that are now used worldwide. In addition, clinicopathological correlation studies have been crucial to generate hypotheses about the pathophysiology of the disease, by establishing that there is a continuum between "normal" aging and AD dementia, and that the amyloid plaque build-up occurs primarily before the onset of cognitive deficits, while neurofibrillary tangles, neuron loss, and particularly synaptic loss, parallel the progression of cognitive decline. Importantly, these cross-sectional neuropathological data have been largely validated by longitudinal in vivo studies using modern imaging biomarkers such as amyloid PET and volumetric MRI.
Building similarity graph...
Analyzing shared references across papers
Loading...
Alberto Serrano‐Pozo
Matthew P. Frosch
Eliezer Masliah
Cold Spring Harbor Perspectives in Medicine
Harvard University
University of California, San Diego
Massachusetts General Hospital
Building similarity graph...
Analyzing shared references across papers
Loading...
Serrano‐Pozo et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69855d387afb769691b69037 — DOI: https://doi.org/10.1101/cshperspect.a006189
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: