Brachial-ankle pulse wave velocity showed limited predictive value for obstructive CAD, yielding low sensitivity (53%) and specificity (50%), and lacked independent correlation with CACS.
Observational (n=174)
Does brachial-ankle pulse wave velocity (baPWV) predict the presence of coronary artery disease in high-risk patients?
Brachial-ankle pulse wave velocity has limited clinical utility as an independent predictor of obstructive coronary artery disease in high-risk patients, as its association with coronary calcium is primarily driven by common risk factors like age.
Effect estimate: r=0.14
p-value: p=0.14
BACKGROUND AND OBJECTIVES: Arterial stiffness has been known as an independent contributory factor for coronary artery disease (CAD). Brachial-ankle pulse wave velocity (baPWV) is widely used as a simple noninvasive measure of arterial stiffness. The aim of our study was to test whether baPWV had predictive value for CAD in the subset of patients with high pretest probability. SUBJECTS AND METHODS: We enrolled 174 consecutive patients who were referred for evaluation of suspected CAD, and who underwent both baPWV measurement and computed tomography (CT) for coronary artery calcium scoring (CACS) as part of a diagnostic work-up. Subsequently, 160 of those patients underwent invasive coronary angiography. The CAD indices consisted of 1) CACS, 2) modified Gensini scoring system, and 3) presence of obstructive CAD and 4) multi-vessel obstructive CAD. RESULTS: baPWV correlated with CACS (r=0.25, p=0.001), but not with modified Gensini scoring (r=0.10, p=0.19). However, after adjustment for factors influencing PWV, baPWV no longer correlated with CACS (r=0.14, p=0.14). By receiver operating characteristic (ROC) curve analysis, baPWV was neither a sensitive nor specific index for predicting the presence of obstructive CAD or multi-vessel obstructive CAD (sensitivity: 53% and 59%; specificity: 50% and 55%, respectively). CONCLUSION: Our findings demonstrated that baPWV is associated with CACS, however, this may be primarily attributed to common risk factors, such as age. Furthermore, baPWV may be of limited value in identifying patients at risk for CAD.
Seo et al. (Fri,) conducted a observational in Suspected coronary artery disease (n=174). Brachial-ankle pulse wave velocity (baPWV) was evaluated on Correlation with coronary artery calcium scoring (CACS) after adjustment for influencing factors (r=0.14, p=0.14). Brachial-ankle pulse wave velocity showed limited predictive value for obstructive CAD, yielding low sensitivity (53%) and specificity (50%), and lacked independent correlation with CACS.