Septal pacing maintained normal left ventricular function indices compared to intrinsic rhythms, whereas right ventricular apical pacing significantly decreased LV dP/dt, Vmax, and Vpm.
Does septal pacing maintain left ventricular function better than apical pacing in young patients with normal cardiac anatomy?
Septal pacing acutely maintains normal left ventricular function in young nonischemic hearts, whereas apical pacing causes immediate hemodynamic deterioration.
Ventricular pacing, typically initiated from a RV apical electrode, inherently causes abnormal biventricular activation, decrease LV function, and causes histopathological changes. Since pacing initiated in childhood can be expected to have a more protracted course compared with the adult, the consequences of this alteration in LV hemodynamics gain added significance among the young pacemaker recipient. The purpose of this study was to evaluate the potential of improving paced LV function by a septal electrode implant site. Acute alterations in cardiac index, LV pressure, and contraction indices, including dP/dt, Vmax, and Vpm, were compared among 22 patients (median age 10 years) with normal cardiac anatomy during intracardiac electrophysiological studies. LV hemodynamics were measured during intrinsic rhythms and following 15 minutes of atrial, RV apical, and septal pacing at an appropriate exercise rate for age of 150 ppm. Results showed a significant decrease in LV dP/dt, Vmax, and Vpm, and increase in LV end-diastolic pressure only with apical pacing. Septal pacing, in spite of loss of any atrial contribution to ventricular filling, maintained comparable indices with intrinsic and atrial paced rhythms. This study demonstrates that normalized LV function is maintained by septal and deteriorates with apical pacing acutely among young, nonischemic hearts. Continued evaluation of appropriate pacing electrode designs to permit septal implant is needed to ensure optimal chronically paced LV function.
Karpawich et al. (Fri,) conducted a other in Normal cardiac anatomy undergoing intracardiac electrophysiological studies (n=22). Septal pacing vs. Right ventricular apical pacing and intrinsic rhythms was evaluated on Acute alterations in cardiac index, LV pressure, and contraction indices (dP/dt, Vmax, and Vpm). Septal pacing maintained normal left ventricular function indices compared to intrinsic rhythms, whereas right ventricular apical pacing significantly decreased LV dP/dt, Vmax, and Vpm.