Electrocardiographic left ventricular hypertrophy with ST depression and negative T wave increased the risk of myocardial infarction (RR 3.78; 95% CI 2.29-6.25) over 7 years.
Cohort (n=11,634)
Does the presence of electrocardiographic left ventricular hypertrophy, ST depression, and negative T wave predict future cardiac events in subjects without known ischaemic heart disease?
Electrocardiographic left ventricular hypertrophy with ST depression and negative T wave changes strongly predict future cardiac events in individuals without known ischemic heart disease.
Relative Risk: 3.78 (95% CI 2.29–6.25)
AIMS: To evaluate the prevalence and the independent prognosis of electrocardiographic left ventricular hypertrophy by voltage only, ST depression and negative T wave, isolated negative T wave and left ventricular hypertrophy plus ST depression and negative T wave for cardiac morbidity and mortality, without known ischaemic heart disease at baseline. METHODS AND RESULTS: Follow-up data from the Copenhagen City Heart Study were used. Subjects were 5243 men and 6391 women, age range 25-74 years. End-points were (1) myocardial infarction, (2) ischaemic heart disease and (3) cardiovascular disease mortality. Relative risk was age- and sex-adjusted, and multivariately adjusted for known cardiovascular risk factors. During 7 years follow-up, left ventricular hypertrophy plus ST depression and negative T wave had an age-adjusted relative risk of 3.78 (95% confidence interval 2.29-6.25) for myocardial infarction, 4.27 (2.95-6.16) for ischaemic heart disease and 3.75 (2.41-5.85) for cardiovascular disease. A negative T wave, ST depression and negative T wave changes, and left ventricular hypertrophy with negative T wave also carry independent prognostic information for myocardial infarction, ischaemic heart disease and cardiovascular disease. CONCLUSIONS: Electrocardiographic left ventricular hypertrophy with ST depression and negative T wave changes are the electrocardiographic abnormalities with the greatest prognostic information for future cardiac events. Electrocardiographic negative T waves, ST depression and negative T wave abnormalities and left ventricular hypertrophy with negative T waves, also have prognostic information.
C Larsen (Fri,) conducted a cohort in No known ischemic heart disease (n=11,634). Electrocardiographic left ventricular hypertrophy plus ST depression and negative T wave was evaluated on Myocardial infarction (RR 3.78, 95% CI 2.29-6.25). Electrocardiographic left ventricular hypertrophy with ST depression and negative T wave increased the risk of myocardial infarction (RR 3.78; 95% CI 2.29-6.25) over 7 years.