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The heterogeneity of the immunoglobulins is the result of three types of amino acid sequence variability: (1) The isotypic variants, which are common to all individuals of the same species and differentiate classes and types of immunoglobulins; (2) The allotypic variants, which distinguish polymorphic forms of immunoglobulins not present in all members of a given species; (3) The idiotypic variants, which characterize individual antibodies and myeloma proteins.
Milstein et al. (Sun,) studied this question.