Mechanosensitive ion channels mediate the feedback from cardiac mechanics to electrical activity, converting mechanical stimuli into electrical signals in ventricular electromechanical function.
The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in 'dynamo mode', the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechanosensitive ion channels, whose properties and pathophysiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electromechanical function.
Köhl et al. (Thu,) conducted a review in Ventricular electrophysiology and mechanosensitive ion channels. Mechanosensitive ion channels mediate the feedback from cardiac mechanics to electrical activity, converting mechanical stimuli into electrical signals in ventricular electromechanical function.