Indwelling aortic catheters reduced platelet survival in rabbits and rats, reflecting the extent of vessel wall injury rather than the amount of thrombus formation.
Do indwelling aortic catheters affect platelet survival and thrombosis in animal models?
Platelet survival reflects the extent and frequency of vessel wall injury rather than serving as an estimate of thrombus formation.
This study examined the relation among platelet survival, thrombosis, and repeated vessel injury. With the use of 51Cr-labeled platelets, indwelling aortic catheters were shown to reduce platelet survival in rabbits and rats. In rabbits, thrombi were observed mainly at the aortic bifurcation and at the tip of the catheter. The amount of thrombus that formed in rabbits with short and long catheters was similar, but platelet survival was shortened only in rabbits with short and long catheters was similar, but platelet survival was shortened only in rabbits with long indwelling aortic catheters. In rats, the aortic catheters did not cause thrombosis, and platelet survival was shortened significantly in rats with both short and long catheters, but was more pronounced in animals with longer catheters. In both rabbits and rats, long aortic catheters caused more extensive vessel injury than the short catheters and this was associated with greater platelet interaction with the vessel wall. Platelet survival cannot be used as an estimate of thrombus formation, but may reflect the extent and frequency of vessel wall injury. thus, shortened platelet survival may represent increased platelet interaction with the damaged arterial wall and increased platelet consumption.
Winocour et al. (Mon,) conducted a other in Thrombosis and vessel injury. Indwelling aortic catheters vs. Short vs long catheters was evaluated on Platelet survival and thrombosis. Indwelling aortic catheters reduced platelet survival in rabbits and rats, reflecting the extent of vessel wall injury rather than the amount of thrombus formation.