Daily ingestion of dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium was associated with acute myocardial infarction in a previously healthy 22-year-old man.
Case Report (n=1)
Simultaneous use of dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium may be associated with acute myocardial infarction and coronary thrombosis in young, healthy individuals.
We describe the case of a previously healthy 22-year-old man who presented with anginal chest pain and was diagnosed with a non-ST-elevation myocardial infarction. For 3 weeks, he had been ingesting the dietary supplements Jack3d® (principal ingredient, 1,3-dimethylamylamine) and Phenorex™ (principal ingredient, Citrus aurantium) daily, before undertaking physical activity. Coronary angiograms revealed a proximal left anterior descending coronary artery thrombus with distal embolization. A combined medical regimen led to resolution of the thrombus. Three months later, the patient was asymptomatic with no evidence of ischemia. The primary ingredients in the sympathomimetic supplements taken by our patient are controversial in the medical community and have been individually associated with adverse cardiac events. There are no safety data on their simultaneous use. We discuss other reports of adverse effects associated with these supplements and recommend that the relevant safety guidelines be revised.
Smith et al. (Sat,) conducted a case report in Acute Myocardial Infarction (n=1). Jack3d (1,3-dimethylamylamine) and Phenorex (Citrus aurantium) was evaluated. Daily ingestion of dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium was associated with acute myocardial infarction in a previously healthy 22-year-old man.