Total Synthesis of (+)‐Asperolide C by Iridium‐Catalyzed Enantioselective Polyene Cyclization

Domino rings: A general synthetic entry into labdane-type diterpenoids has been developed based on an iridium-catalyzed enantioselective polyene cyclization cascade. The potential of this process is demonstrated in the first total synthesis of the tetranorlabdane diterpene asperolide C (PMB=p-methoxybenzyl, TMS= trimethylsilyl). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.