Does the mechanism of reduced GFR (renal dysfunction phenotype) influence mortality in heart failure populations?
The mechanism underlying renal impairment, rather than just the reduction in GFR, may be the key driver of poor survival in heart failure patients.
The association between RI and poor survival observed in heart failure populations appears to be contingent not simply on the presence of a reduced GFR, but possibly on the mechanism by which GFR is reduced.
Testani et al. (Fri,) studied this question.
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