Studies of the metabolism and distribution of fibrinogen in healthy men with autologous 125-I-labeled fibrinogen.

A few studies of the metabolism and distribu- tion of fibrinogen in healthy men have been re- ported (1-3), but because of the lability of fibrino- gen and the methods employed the earlier of these do not appear to have been entirely successful. Recent advances in the preparation of fibrinogen- 131I (4, 5) and in the mathematics of its kinetic behavior (6) have made possible more reliable and extensive studies. Observations have therefore been made on 12 healthy male volunteers with autologous fibrinogen labeled with 125J.