The failing heart exhibited noradrenaline depletion, with catecholamine concentrations of 0.53 µg/g in the failing left ventricle versus 2.64 µg/g in the nonfailing right atrium.
Observational (n=42)
This study confirms the depletion of noradrenaline in the failing human heart and demonstrates regional variations in cardiac catecholamine concentrations.
Absolute Event Rate: 0.53% vs 2.64%
A trihydroxyindole fluorescent technique was used to measure the concentration of catecholamines in heart muscle taken from 42 patients undergoing open heart surgery. Noradrenaline was the dominant catecholamine and its depletion in the failing heart was confirmed. The distribution of catecholamines within the heart was such that the highest value, 2.64 +/- 0.68 microgram/g, was found in the nonfailing right atrium and the lowest, 0.53 +/- 0.40 microgram/g, in the failing left ventricle.
Petch et al. (Thu,) conducted a observational in Heart failure (n=42). Heart failure vs. Nonfailing heart was evaluated on Catecholamine concentration in heart muscle. The failing heart exhibited noradrenaline depletion, with catecholamine concentrations of 0.53 µg/g in the failing left ventricle versus 2.64 µg/g in the nonfailing right atrium.