Ena/VASP proteins function as 'anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments, resolving previous contradictions regarding their role.
Resolves contradictions in the field by proposing that Ena/VASP proteins act as anti-capping proteins to regulate actin-dependent processes.
Ena/VASP proteins are actin-binding proteins that localize to actin stress fibres, the tips of filopodia and the lamellipodial leading edge. In the past few years, a number of seemingly conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in both promotion and inhibition of actin-dependent processes. Recent discoveries resolve these contradictions and suggest a novel mechanism of Ena/VASP function, in which the proteins function as 'anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments.
Krause et al. (Thu,) reported a review. Ena/VASP proteins was evaluated. Ena/VASP proteins function as 'anti-capping' proteins that antagonize capping proteins at the barbed end of actin filaments, resolving previous contradictions regarding their role.