Cardiac-specific inducible and conditional gene targeting technologies in mice provide clinically relevant models to elucidate the genetic pathways of heart development and disease.
This review summarizes the technologies and limitations of conditional and inducible gene targeting in mouse models for cardiovascular research.
Mouse genetic engineering has revolutionized our understanding of the molecular and genetic basis of heart development and disease. This technology involves conditional tissue-specific and temporal transgenic and gene targeting approaches, as well as introduction of polymorphisms into the mouse genome. These approaches are increasingly used to elucidate the genetic pathways underlying tissue homeostasis, physiology, and pathophysiology of adult heart. They have also led to the development of clinically relevant models of human cardiac diseases. Here, we review the technologies and their limitations in general and the cardiovascular research community in particular.
Doetschman et al. (Thu,) conducted a review in Heart development and disease. Cardiac-specific inducible and conditional gene targeting was evaluated. Cardiac-specific inducible and conditional gene targeting technologies in mice provide clinically relevant models to elucidate the genetic pathways of heart development and disease.
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