January 11, 2013

Genetics and Outcome of Atypical Hemolytic Uremic Syndrome

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Abstract

Mortality rate was higher in children than adults with aHUS, but renal prognosis was worse in adults than children. In children, the prognosis strongly depends on the genetic background.

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Cite This Study

Frémeaux‐Bacchi et al. (Fri,) studied this question.

synapsesocial.com/papers/69d778caf44a16d01ef314ab https://doi.org/https://doi.org/10.2215/cjn.04760512

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function2012 · 141 citations
2Clinical Features of Anti-Factor H Autoantibody–Associated Hemolytic Uremic Syndrome2010 · 296 citations
3Mutations in complement C3 predispose to development of atypical haemolytic uraemic syndrome2007 · 154 citations
4The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility factors in factor H and membrane cofactor protein: evidence from two independent cohorts2005 · 171 citations
5Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome2010 · 309 citations