The provided text consists only of journal masthead information and contains no study data or findings regarding the effect of clopidogrel in rats.
Does clopidogrel inhibit thrombin generation and venous thrombus formation in a rat model?
Clopidogrel inhibits thrombin generation and venous thrombus formation in rats, demonstrating a close relationship between platelet activation and blood coagulation.
Clopidogrel (25 mg/kg, p.o.), a potent and selective inhibitor of ADP-induced platelet aggregation, significantly inhibited, in the presence of platelets, ex vivo thrombin generation triggered by low concentrations of tissue factor. Clopidogrel reduced the area under the curve (23%, p <0.05) and the thrombin peak concentration (35%, p <0.05) but did not affect the lag phase of thrombin generation. Under the same experimental conditions, heparin (100 microg/ml) inhibited thrombin generation mostly by delaying and by reducing the burst of thrombin. In a stasis-induced venous thrombosis model in rats under low thrombogenic challenge, clopidogrel inhibited thrombus formation (ED50 = 7.9+/-1.5 mg/kg, p.o. - n = 10), confirming the existence of a close relationship between platelet activation and thrombin generation leading to blood coagulation and venous thrombosis.
Hérault et al. (1999) studied Thrombin generation. Clopidogrel was evaluated on Thrombin generation in platelet-rich plasma. The provided text consists only of journal masthead information and contains no study data or findings regarding the effect of clopidogrel in rats.