Electrocardiographic left ventricular hypertrophy diagnosed by Sokolow-Lyon criteria was independently associated with an increased risk of all-cause mortality (HR 2.84) after multivariable adjustment including ambulatory blood pressure.
Cohort (n=387)
No
Does EKG-LVH diagnosed by Sokolow-Lyon or Cornell criteria predict all-cause mortality in patients with chronic kidney disease?
In patients with CKD, EKG-LVH diagnosed by Sokolow-Lyon criteria, but not Cornell criteria, carries independent prognostic information for all-cause mortality.
Hazard Ratio: 2.84 (95% CI 1.5–5.37)
p-value: p=<0.001
BACKGROUND AND OBJECTIVES: The diagnosis of left ventricular hypertrophy (LVH) has prognostic value in the general population. However, among those with chronic kidney disease (CKD), the determinants of electrocardiographic (EKG) LVH and its prognostic value are not clear. DESIGN, SETTING, PARTICIPANTS, however, multivariable adjustments made EKG-LVH significant. A statistically significant relationship was seen between mortality and Cornell criteria; however, multivariable adjustments made EKG-LVH nonsignificant. CONCLUSIONS: The Sokolow-Lyon and Cornell EKG-LVH criteria cannot be used interchangeably to diagnose LVH or determine prognosis. Among those with CKD, ambulatory systolic BP predicts all-cause mortality. Moreover, the duration and severity of BP elevation presumably reflected in EKG-LVH diagnosed by Sokolow-Lyon criteria is also of prognostic significance; the Cornell criteria do not carry independent prognostic information.
Agarwal et al. (Fri,) conducted a cohort in Chronic Kidney Disease (n=387). Electrocardiographic Left Ventricular Hypertrophy (Sokolow-Lyon criteria) vs. Absence of EKG-LVH was evaluated on All-cause mortality (HR 2.84, 95% CI 1.50-5.37, p=<0.001). Electrocardiographic left ventricular hypertrophy diagnosed by Sokolow-Lyon criteria was independently associated with an increased risk of all-cause mortality (HR 2.84) after multivariable adjustment including ambulatory blood pressure.