July 13, 2004

Organocatalytic Asymmetric Epoxidation of Olefins by Chiral Ketones

YSYian ShiCatalytic Materials (United States)

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Abstract

Chiral ketones have been shown to be effective organocatalysts for asymmetric epoxidation of olefins with broad substrate scope. High enantioselectivity has been obtained for a wide variety of trans and trisubstituted olefins, as well as a number of cis olefins, with encouragingly high ee's for some terminal olefins. The stereochemical outcome of the reaction can be rationalized by a spiro transition state model.

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Yian Shi (Tue,) studied this question.

synapsesocial.com/papers/6a5dfa8c69f6c368eabc3aa1 https://doi.org/https://doi.org/10.1021/ar030063x

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