The eNOS haplotype 'C Glu a' was significantly more common in gestational hypertensive and preeclamptic women compared to healthy pregnancies (17% and 17% vs 5%; p=0.0061).
Case-Control (n=326)
Are specific eNOS haplotypes associated with the development of gestational hypertension or preeclampsia in pregnant women?
Specific eNOS haplotypes, rather than individual genotypes alone, are associated with the development of hypertensive disorders of pregnancy.
Absolute Event Rate: 17% vs 5%
p-value: p=0.0061
AIMS: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been inconsistently associated with preeclampsia. We compared genotype and haplotype frequencies of three eNOS gene polymorphisms in normotensive and hypertensive pregnancies. METHODS: Genotypes and haplotypes for eNOS polymorphisms (T-786C, Glu298Asp and intron 4 b/a) were determined in 326 pregnant women (110 healthy pregnancies, 103 gestational hypertensives and 113 preeclamptic). RESULTS: No differences were observed in the frequencies of genotypes and alleles of the three polymorphisms among the groups (all p > 0.05). However, the haplotype 'T Glu a' was more common in healthy pregnancies than in gestational hypertensives or preeclamptic (20 vs 6 and 6%, respectively; p < 0.0032). Conversely, the haplotype 'C Glu a' was more common in gestational hypertensives and preeclamptic than in healthy pregnancies (17 vs 17 and 5%; p = 0.0061). CONCLUSION: These findings suggest a contribution of eNOS haplotypes to the development of hypertensive disorders of pregnancy that is obscured when specific eNOS genotypes alone are considered.
Sandrim et al. (Wed,) conducted a case-control in Gestational Hypertension or Preeclampsia (n=326). eNOS haplotypes vs. Normotensive pregnancies was evaluated on Frequency of haplotype 'C Glu a' (p=0.0061). The eNOS haplotype 'C Glu a' was significantly more common in gestational hypertensive and preeclamptic women compared to healthy pregnancies (17% and 17% vs 5%; p=0.0061).
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