The T allele and TT homozygosity of the CYP11B2 -344C/T polymorphism were more frequent in patients with idiopathic low renin hypertension compared to other hypertensives and normotensive controls.
Case-Control (n=287)
Is the -344C/T polymorphism of the CYP11B2 gene associated with idiopathic low renin hypertension and abnormal aldosterone secretion?
The -344C/T polymorphism of the CYP11B2 gene may contribute to the abnormal regulation of aldosterone secretion in idiopathic low renin hypertension.
Most patients with low renin essential hypertension are not qualitatively different from patients with idiopathic hyperaldosteronism, as in both conditions aldosterone secretion is not appropriately reduced. The aim of the study was to investigate allele and genotype frequencies of the -344C/T polymorphism, located in the promoter region of the aldosterone synthase gene, in 83 patients with idiopathic low renin hypertension characterized by an increased aldosterone to renin ratio, including both patients with low renin essential hypertension (n=53) and subjects with idiopathic hyperaldosteronism (n=30), compared with 78 patients with normal to high renin essential hypertension and 126 normotensive control subjects. The relationship of -344C/T genotypes to basal and postcaptopril plasma aldosterone/plasma renin activity ratio was also examined in the entire hypertensive population. An increased frequency of the T allele and a relative excess of TT homozygosity over CC homozygosity were found in patients with idiopathic low renin hypertension in comparison with both normal to high renin hypertensives and normotensive controls. A higher post-captopril aldosterone to renin ratio was found in the hypertensives with TT genotype than in those with CC genotype, and TT+TC genotypes were associated with a smaller decrease in the aldosterone-to-renin ratio elicited by captopril administration. The present study suggests that the -344C/T polymorphism, or a functional variant in linkage disequilibrium with it, may play a role in the abnormal regulation of aldosterone secretion in idiopathic low renin hypertension.
Ermanno Rossi (Sat,) conducted a case-control in Idiopathic low renin hypertension (n=287). -344C/T polymorphism of CYP11B2 gene (T allele / TT genotype) vs. C allele / CC genotype, and normotensive/normal-high renin controls was evaluated on Allele and genotype frequencies of the -344C/T polymorphism and relationship to basal and postcaptopril plasma aldosterone/plasma renin activity ratio. The T allele and TT homozygosity of the CYP11B2 -344C/T polymorphism were more frequent in patients with idiopathic low renin hypertension compared to other hypertensives and normotensive controls.