August 15, 2012Open Access
Chronic pain as a manifestation of potassium channel-complex autoimmunity
Key Points
Key points are not available for this paper at this time.
Abstract
Chronic idiopathic pain is a syndromic manifestation of VGKC-complex autoimmunity. Hyperexcitability of nociceptive pathways is implicated. CASPR2-IgG significantly associates with pain, but in most patients the antigenic VGKC-complex molecule remains to be determined. VGKC-complex autoimmunity represents an important new direction for pain research and therapy.