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A novel post-synthesis analysis tool is presented which evaluates quality of the organic preparation based on yield, cost, safety, conditions and ease of workup/purification. The proposed approach is based on assigning a range of penalty points to these parameters. This semi-quantitative analysis can easily be modified by other synthetic chemists who may feel that some parameters should be assigned different relative penalty points. It is a powerful tool to compare several preparations of the same product based on safety, economical and ecological features.
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Koen Van Aken
Lucjan Strękowski
Luc Patiny
Beilstein Journal of Organic Chemistry
SHILAP Revista de lepidopterología
École Polytechnique Fédérale de Lausanne
Georgia State University
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Aken et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69d8972e18b0ca7f91d1856d — DOI: https://doi.org/10.1186/1860-5397-2-3