Antihypertensive therapies should target blood pressure-independent mechanisms like oxidative stress, inflammation, and arterial baroreflex dysfunction to optimize stroke prevention.
Do antihypertensive therapies with blood pressure-independent effects prevent stroke in patients with hypertension better than conventional treatment?
Understanding the mechanisms of hypertension-induced stroke, such as oxidative stress and inflammation, may help develop new antihypertensive strategies with blood pressure-independent benefits for stroke prevention.
Stroke is a major cause of disability and death worldwide. Prevention aimed at risk factors of stroke is the most effective strategy to curb the stroke pandemic. Hypertension is one of the most important risk factors for stroke. Despite the substantial evidence of the benefits of lowering blood pressure, conventional treatment does not normalize the burden of major cardiovascular events in patients with hypertension. Fully understanding the factors involved in the hypertension-induced stroke helps to develop new strategies for stroke prevention. Antihypertensive therapies selected should have positive blood pressure-independent effects on stroke risk. This review summarizes the factors involved in the hypertension-induced stroke, such as oxidative stress, inflammation, and arterial baroreflex dysfunction, and potential strategies for its prevention, therefore, provides clues for clinicians.
Yu et al. (Fri,) conducted a review in Hypertension and Stroke. Antihypertensive therapies was evaluated. Antihypertensive therapies should target blood pressure-independent mechanisms like oxidative stress, inflammation, and arterial baroreflex dysfunction to optimize stroke prevention.