Direct Substitution of the Hydroxy Group in Alcohols with Silyl Nucleophiles Catalyzed by Indium Trichloride

Straightforward substitution: An excellent combination of a silyl nucleophile and indium catalyst was used to accomplish the dehydroxylation/alkylation of alcohols under nearly neutral conditions (see scheme, Si=silyl group) even though this type of reaction usually requires at least an equimolar amount of acid. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2004/z53121ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.