Cardiac AL amyloidosis was associated with a higher prevalence of intraventricular blocks compared to no cardiac involvement (27.5% vs. 16.5%, P<0.05), which predicted higher mortality (P=0.0001).
Cohort (n=344)
Absolute Event Rate: 27.5% vs 16.5%
p-value: p=<0.05
BACKGROUND AND PURPOSE: To evaluate the prevalence and the prognostic implications of conduction delays in a large cohort of cardiac AL patients. METHODS: Echo Doppler and 12-lead ECG were collected in 344 consecutive patients in whom diagnosis of AL amyloidosis was concluded between 2008 and 2010. Patients were subdivided according to the presence (n = 240) or absence (n = 104) of cardiac involvement. RESULTS: When compared with patients without myocardial involvement, cardiac AL was associated with prolonged PQ, QRS, QT and QTc intervals (P < 0.05), and with higher prevalence of intraventricular blocks (27.5% vs. 16.5%, P < 0.05), that was associated with higher wall thickness, worse diastolic and regional systolic function, higher NT-proBNP values (all P < 0.05), and higher mortality (P = 0.0001; median follow-up: 402 days). CONCLUSION: Intraventricular conduction delays have a negative prognostic impact in patients with cardiac AL amyloidosis. Their presence should not be overlooked in the diagnostic workup, prompting a more accurate cardiological support.
Boldrini et al. (Sun,) conducted a cohort in AL amyloidosis (n=344). Cardiac involvement vs. No cardiac involvement was evaluated on Intraventricular blocks (p=<0.05). Cardiac AL amyloidosis was associated with a higher prevalence of intraventricular blocks compared to no cardiac involvement (27.5% vs. 16.5%, P<0.05), which predicted higher mortality (P=0.0001).
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