This review discusses techniques for measuring pulmonary vascular impedance spectra and right ventricular function to better assess proximal and peripheral arterial structure in pulmonary hypertension.
Pulmonary vascular impedance spectra (PVZ) and ventricular-vascular coupling analyses provide a more comprehensive assessment of right ventricular and pulmonary vascular function than pulmonary vascular resistance alone.
Long-standing pulmonary hypertension causes significant peripheral and proximal arterial remodeling and right ventricular dysfunction. The clinical metric most often used to assess the progression of PH is the pulmonary vascular resistance (PVR). However, even when measured from multipoint pressure-flow curves, PVR provides information only on the peripheral arterial function, not the proximal arterial function and gives only an incomplete description of all the forces that oppose right ventricular (RV) flow output. Pulmonary vascular impedance spectra (PVZ) capture the impact of proximal and peripheral arterial structure and function on RV function. Analyses of ventricular-vascular coupling give insight into the efficiency of mechanical and metabolic interactions between the right ventricle and the pulmonary vasculature. Here we review techniques for measuring PVZ in humans and animal models and for determining RV function.
Chesler et al. (Tue,) conducted a review in Pulmonary hypertension. Techniques for measuring pulmonary vascular impedance spectra (PVZ) and right ventricular function was evaluated. This review discusses techniques for measuring pulmonary vascular impedance spectra and right ventricular function to better assess proximal and peripheral arterial structure in pulmonary hypertension.