Age of onset of hypertension and risk of dementia in the oldest‐old: The 90+ Study

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Dementia (n=559). Intervention: Hypertension onset at older ages (80-89 years or 90+ years) vs. No hypertension. Primary outcome: Dementia (HR 0.37, p=.004).

Key Result

Hypertension onset at age 80 to 89 years (HR 0.58, P=0.04) and at age 90 or older (HR 0.37, P=0.004) was associated with a significantly lower risk of dementia compared to no hypertension.

Study Design

Type

Cohort (n=559)

Structured PICO

Does older age of onset of hypertension reduce the risk of dementia in people aged 90+?

Population

559 adults aged 90 years and older without dementia, followed every 6 months for up to 10 years.

Exposure

Hypertension onset at age 80-89 years or 90+ years

Comparator

Participants without hypertension

Outcome

Development of dementiahard clinical

Developing hypertension at older ages (80+ years) is associated with a significantly lower risk of dementia in the oldest-old compared to those without hypertension.

Main Result

Hazard Ratio: 0.37

p-value: p=.004

Abstract

INTRODUCTION: We investigated the association between age of onset of hypertension and dementia risk in an oldest-old cohort. METHODS: Participants are from The 90+ Study, a population-based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study. We estimated hypertension onset age using self-reported information from The 90+ Study and Leisure World Cohort Study, collected about 20 years earlier. A total of 559 participants without dementia were followed every 6 months for up to 10 years. RESULTS: A total of 224 participants developed dementia during follow-up (mean = 2.8 years). Compared with those without hypertension, participants whose hypertension onset age was 80 to 89 years had a lower dementia risk (hazard ratio = 0.58, P = .04) and participants with an onset age of 90+ years had the lowest risk (hazard ratio = 0.37, P = .004). DISCUSSION: Developing hypertension at older ages may protect against dementia. Understanding the mechanisms for this lower risk is important for determining ways to prevent dementia in the very elderly.

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Cite This Study

Corrada et al. (Mon,) conducted a cohort in Dementia (n=559). Hypertension onset at older ages (80-89 years or 90+ years) vs. No hypertension was evaluated on Dementia (HR 0.37, p=.004). Hypertension onset at age 80 to 89 years (HR 0.58, P=0.04) and at age 90 or older (HR 0.37, P=0.004) was associated with a significantly lower risk of dementia compared to no hypertension.

synapsesocial.com/papers/6a242709749b6bda219f5cdc https://doi.org/https://doi.org/10.1016/j.jalz.2016.09.007

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