May 7, 2026
Ver artículo completoCopeptin Helps in the Early Detection of Patients With Acute Myocardial Infarction
PICO estructurado
Does adding copeptin to cardiac troponin I improve the early rule-out of acute myocardial infarction in patients presenting to the emergency department with chest pain within 6 hours of onset?
P
Población
1,967 patients with chest pain presenting to an emergency department within 6 hours of pain onset.
I
Intervención
Copeptin levels (<14 pmol/L) in combination with contemporary sensitive cardiac troponin I (cTnI <99th percentile) and a nondiagnostic electrocardiogram.
C
Comparador
Initial cardiac troponin I (cTnI) alone.
O
Resultado
Diagnosis of acute myocardial infarction (AMI), adjudicated by 2 independent cardiologists blinded to copeptin results.hard clinical
Adding copeptin to sensitive cardiac troponin I allows for the safe and rapid rule-out of acute myocardial infarction in over half of emergency department patients presenting with early chest pain.
Resumen
OBJECTIVES: The goal of this study was to demonstrate that copeptin levels 14 pmol/l in 23 (72%) of 32 patients. Non-ST-segment elevation myocardial infarctions undetected by cTnI at 0 h were detected with copeptin >14 pmol/l in 10 (53%) of 19 patients. Projected average time-to-decision could be reduced by 43% (from 3.0 h to 1.8 h) by the early rule out of 58% of patients. Both abnormal copeptin and cTnI were predictors of death at 180 days (p 99% in patients presenting with suspected acute coronary syndromes. This combination has the potential to rule out AMI in 58% of patients without serial blood draws.