Vascular dementia was not associated with ACE, MTHFR, or FVL genotypes, while APOE epsilon4 allele frequency was 26% in VD (P=0.07) and 30% in AD (P=0.016) vs 15% in controls.
Case-Control (n=130)
Are genetic risk factors for vascular disease (ACE, MTHFR, Factor V Leiden) and APOE epsilon4 associated with vascular dementia?
Genetic risk factors for vascular disease (ACE, MTHFR, FVL) are not associated with vascular dementia, suggesting its pathogenesis may differ from other vascular diseases.
Absolute Event Rate: 26% vs 15%
p-value: p=0.07
BACKGROUND AND PURPOSE: There is a growing interest in the use of genetic markers in the differential diagnosis of dementia. In the current study we examined the usefulness of genetic risk factors for vascular disease as markers for vascular dementia (VD). METHODS: The groups included 41 patients with VD, 49 patients with dementia of the Alzheimer's type, and 40 age-matched control subjects without dementia. These patients were genotyped for vascular disease-associated polymorphisms in the genes coding for methylenetetrahydrofolate reductase (MTHFR), angiotensin-converting enzyme (ACE), factor V Leiden (FVL), and a common genetic risk factor for AD, apolipoprotein E epsilon4 (APOE epsilon4). RESULTS: There was no significant association between ACE, MTHFR, and FVL genotypes with VD whether compared with subjects with AD or with control subjects. There was a higher frequency of APOE epsilon4 alleles in patients with AD (30%, P=0.016) and VD (26%, P=0.07) compared with control subjects (15%). CONCLUSIONS: VD is not associated with the genetic risk factors for vascular disease examined in this study, indicating that the pathogenesis of VD may differ from other vascular diseases.
Chapman et al. (Wed,) conducted a case-control in Vascular dementia and Alzheimer's dementia (n=130). ACE, MTHFR, FVL, and APOE epsilon4 polymorphisms vs. Age-matched control subjects without dementia was evaluated on Frequency of APOE epsilon4 alleles (p=0.07). Vascular dementia was not associated with ACE, MTHFR, or FVL genotypes, while APOE epsilon4 allele frequency was 26% in VD (P=0.07) and 30% in AD (P=0.016) vs 15% in controls.