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Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine. Allogeneic stem-cell transplantation resulted in disease remission in one patient.
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Erik‐Oliver Glocker
Daniel Kotlarz
Kaan Boztuǧ
New England Journal of Medicine
Harvard University
National Institutes of Health
University College London
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Glocker et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69dc3369d50c49528a9f54e8 — DOI: https://doi.org/10.1056/nejmoa0907206
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