Does LCZ696 attenuate cardiac remodeling and dysfunction after myocardial infarction compared to stand-alone neprilysin inhibitor or angiotensin receptor blocker?
LCZ696 provides superior attenuation of cardiac remodeling, fibrosis, and hypertrophy post-MI compared to ARB or neprilysin inhibitor alone.
LCZ696 attenuated cardiac remodeling and dysfunction after MI. This may be contributed to by superior inhibition of LCZ696 on cardiac fibrosis and cardiac hypertrophy than either stand-alone neprilysin inhibitor or angiotensin receptor blocker.
Lueder et al. (Sat,) studied this question.