Low-frequency band (1-11 Hz) spectral features of body surface potential maps identified myocardial infarction patients at risk for ventricular tachycardia with a predictive accuracy of 74+/-6%.
Observational (n=135)
Does the low-frequency component of body surface potential maps identify post-infarction patients at risk for ventricular tachycardia?
The low-frequency band (1-11 Hz) of signal-averaged body surface potential maps can identify post-MI patients at risk for ventricular tachycardia, challenging the established notion that only high-frequency components carry arrhythmogenic diagnostic information.
Effect estimate: predictive accuracy of 74+/-6%
p-value: p=<0.0001
AIMS: To investigate the ability of spectral features of signal-averaged body-surface potential maps in identifying post-infarction patients who are at risk of developing ventricular tachycardia. METHODS AND RESULTS: We recorded 120 lead body surface potential maps during sinus rhythm in 135 subjects (45 patients with healed myocardial infarction but no history of ventricular tachycardia, 45 patients with both healed myocardial infarction and at least one episode of sustained ventricular tachycardia, and 45 normal subjects) and analysed spectral features of body surface potential maps selected on the basis of isoharmonic maps for given bands of the frequency spectrum. We found that in the low-frequency band (1-11 Hertz), the group-mean power spectra of leads located at isoharmonic map maxima were significantly different (P<0.0001) between the two groups of myocardial infarction patients. We estimated that this single feature alone can prospectively identify myocardial infarction patients at risk for ventricular tachycardia with a predictive accuracy of 74+/-6%. CONCLUSION: Our results suggest that the bulk of diagnostic information associated with arrhythmogenicity resides in the low-frequency band of the power spectrum. This finding is at variance with the established notion that only the high-frequency component of signal-averaged electrocardiograms carries such information.
Meeder et al. (Sun,) conducted a observational in Healed myocardial infarction and ventricular tachycardia (n=135). Low-frequency band (1-11 Hertz) spectral features of body surface potential maps vs. Patients with healed myocardial infarction but no history of ventricular tachycardia was evaluated on Difference in group-mean power spectra of leads located at isoharmonic map maxima between MI patients with and without ventricular tachycardia (predictive accuracy of 74+/-6%, p=<0.0001). Low-frequency band (1-11 Hz) spectral features of body surface potential maps identified myocardial infarction patients at risk for ventricular tachycardia with a predictive accuracy of 74+/-6%.
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